Breast cancer: present and future

Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide. Today, even though major breast cancer subtypes have been characterized, i.e., luminal A, luminal B, HER2-positive, and triple negative, little is known about the heterogeneity of breast cancer in blood. In particular, phosphoproteins secreted or shed by cancer cells constitute a largely overlooked source of biomarker candidates that could be correlated with breast cancer subtypes and/or disease status.